INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 01 November 2018 (01.11.2018) WIPO I PCT o iimion ono oIIIDIDIIIII11010111Dl o ifloio (10) International Publication Number WO 2018/200638 A4 (51) International Patent Classification: A61B 90/00 (2016.01) A61L 31/00 (2006.01) A61L 31/04 (2006.01) A61N 1/05 (2006.01) (21) International Application Number: PCT/US2018/029305 (22) International Filing Date: DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: with international search report (Art. 21(3)) with amended claims (Art. 190)) with information concerning one or more priority claims considered void (Rule 26bis.2(d)) Date of publication of the amended claims: 06 December 2018 (06.12.2018) 25 April 2018 (25.04.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 15/496,578 25 April 2017 (25.04.2017) US (63) Related by continuation (CON) or continuation-in-part (CIP) to earlier applications: US 14/036,405 (CIP) Filed on 25 September 2013 (25.09.2013) US 61/705,251 (CIP) Filed on 25 September 2012 (25.09.2012) (71) Applicant: AXOGEN CO
