Comes Franchini, Mauro,Saettone, Paolo,Fernández, Javier,Villar, Claudio Jesús,Lombó, Felipe
申请号：
IT201800003441
公开号：
IT201800003441A1
申请日:
2018.03.12
申请国别(地区):
IT
年份:
2019
代理人:
摘要：
The present invention relates to a polyhydroxyalkanoate (PHA) containing 3-hydroxybutyrate monomeric units for use in the prevention of colorectal cancer (CRC) by oral administration. Preferably, the PHA is polyhydrobutyrate (PHB). This is the surprising result of a non-pharmacological preclinical trial approach, which has been explored for prevention of CRC via the oral administration of a PHA in a rat model. The oral administration may be an enteral administration to a subject, e.g. to a subject that has a predisposition in developing CRC or has already shown at least one clinical symptom which is typical of an early stage of CRC. Alternatively, the oral administration may be a dietary administration, which can be directed to a vast majority of population, which wishes to obtain a preventive effect against the onset of CRC.
