The present invention is related to an antibody having therapeutic effect of tumor. Namely, the present invention is related to an antibody binding to B7-H3 and exhibiting anti-tumor activity. The subject of the present invention is to provide a medicament having therapeutic effect of tumor. The solution of the present invention is to acquire an anti-B7-H3 antibody which binds to B7-H3 and exhibits anti-tumor activity, and a medical composition for treatment of tumor containing the antibody and the like.
