The present invention relates to a composition for inhibiting cancer metastasis using apoptotic cells. Particularly, when a conditioned medium was prepared by co-cultivating macrophages and the apoptotic cells, and a mouse lung adenocarcinoma cell 344SQ with EMT induced through TGF-β1 was treated with the conditioned medium, inhibition of EMT, migration, and penetration was confirmed, and inhibition of EMT, migration, and penetration in an A549 cell, which is a human non-small cell lung cancer (NSCLS) cell line, was confirmed. In addition, the same results of cancer metastasis and invasion inhibition were confirmed in various human cancer cell lines such as breast cancer, colon cancer, and prostate cancer.La présente invention concerne une composition pour inhiber la métastase cancéreuse au moyen de cellules apoptotiques. En particulier, lorsqu'un milieu conditionné est préparée par co-culture de macrophages et de cellules apoptotiques, et une cellule d'adénocarcinome pulmonaire de souris 344 SQ avec EMT induit par TGF-β1 a été traitée avec le milieu conditionné, inhibition d'EMT, migration, et une pénétration a été confirmée, et l'inhibition d'EMT, la migration et la pénétration dans une cellule A549, qui est une lignée cellulaire de cancer du poumon non à petites cellules (CPNPC) humain a été confirmée. En outre, les mêmes résultats d'inhibition de métastase et d'invasion cancéreuse ont été confirmés dans différentes lignées cellulaires de cancers humains tels que le cancer du sein, le cancer du colon et le cancer de la prostate.본 발명은 사멸화된 세포(apoptotic cells)를 이용한 암 전이 억제용 조성물에 관한 것으로, 구체적으로 마크로파지(macrophages)와 사멸화된 세포를 공동 배양하여 조건화된 배양액(conditioned meium)을 제조하였으며, 이를 TGF-β1으로 EMT를 유도한 마우스 폐선암세포 344SQ에 처리한 결과, 344SQ 세포의 EMT, 이동 및 침투가 억제됨을 확인하였으며, 인간 비-소세포 폐암(NSCLS) 세포주인 A549 세포에서도 EMT, 이동 및 침투 억제 효과를 확인하였고, 유방암, 결장암 및 전립선암 등 다양한 인간 암세포주에서 상기 결과와 동일하게 암 전이 및 침윤이 억제됨을 확인하였다.
