Morphinan derivatives and compositions containing morphinan derivatives for use in treating disorders associated with autoimmunity, inflammation or infection
The present invention provides a morphinan derivative and a composition containing the morphinan derivative for use in treating disorders related to autoimmunity, inflammation or infection. The present invention provides a novel Toll-like receptor 4, TLR-4 antagonist, and more specifically, the novel TLR-4 antagonist is morphinan. And the use of the morphinan derivative in the treatment of diseases and / or disorders mediated by TLR-4, such as autoimmune diseases, inflammatory diseases and infectious diseases, and pharmaceutical compositions containing the morphinan derivative Offer things. [Selection figure] nothing【課題】モルフィナン誘導体と自己免疫、炎症または感染に関連する障害の治療に用いるモルフィナン誘導体含有組成物の提供。【解決手段】本発明は新規的なＴｏｌｌ様受容体４（ｔｏｌｌ－ｌｉｋｅ ｒｅｃｅｐｔｏｒ ４，ＴＬＲ－４）の拮抗薬を提供し、より具体的には、該新規的なＴＬＲ－４拮抗薬がモルフィナンから誘導され、さらに、該モルフィナン誘導体の自己免疫疾患、炎症性疾病、感染性疾病などのＴＬＲ－４により媒介される疾病及び（または）障害の治療における用途、及び該モルフィナン誘導体を含有する医薬組成物を提供する。【選択図】無
