KRAH DAVID L.,DEHAVEN JILL,KRISS JENNIFER A.,BARR COLLEEN M.,YAGODICH MARY
申请号：
CL2016003181
公开号：
CL2016003181A1
申请日:
2016.12.12
申请国别(地区):
CL
年份:
2017
代理人:
摘要：
The invention provides an inactivated varicella zoster virus (VZV), and compositions and vaccines comprising said inactivated VZV, wherein the infectivity of the VZV is undetectable and wherein the inactivated VZV induces an immune response against VZV when administered to a patient. In embodiments of the compositions described herein, the VZV is inactivated with gamma radiation. The invention also provides a method of preparing an inactivated VZV vaccine, the method comprising gamma irradiating a sample comprising a VZV using from about 5 kGy to about 50 kGy of gamma radiation. Also provided by the invention herein is a method of treatment of or immunization against HZ or other disease associated with the reactivation of VZV, the method comprising administering to a subject a vaccine or pharmaceutical composition comprising a therapeutically effective amount of an inactivated VZV and a pharmaceutically acceptable carrier, wherein the VZV is inactivated by gamma irradiation.Se describe un virus varicela zóster VVZ inactivado, y composiciones que lo comprenden. Preferentemente, el VVZ deriva de la cepa Oka y está inactivado mediante irradiación gamma. Además, se describe un método para preparar un VVZ inactivado que comprende someter dicho VVZ a irradiación gamma 5-50 kGy
