КЭМПБЕЛЛ Кэри В. (US),КЛИК Роберт Л. (US),ХОЛЛАНД Тереза А. (US),КРАНЦЛЕР Тейн Л. (US),ЛИ Мэй (US),ТРАПП Бенджамин М. (US)
申请号：
RU2013144591/15
公开号：
RU2013144591A
申请日:
2012.03.02
申请国别(地区):
RU
年份:
2015
代理人:
摘要：
1. A medical device comprising: (a) an expandable member (b) a coating comprising a therapeutic agent disposed around said expandable member (c) the shell located around said cover, wherein said shell has a microstructure with a variable permeability, bounding initially untargeted transfer of the therapeutic agent through said casing when said casing is substantially sealed microstructure (d) wherein said shell and a therapeutic agent are located substantially between the surfaces Stu expandable member and the shell and (e) wherein during expansion of said expandable member and said casing shell has an open microstructure and provides the transfer of said therapeutic agent to a region outside of said obolochki.2. The medical device of claim 1, wherein said coating and the therapeutic agent are transferred to the region outside of said obolochki.3. The medical device of claim 1, wherein said jacket provides rapid transfer of said coating and the therapeutic agent to the region outside the obolochki.4. The medical device of claim 1, wherein said outer shell is treated with a wetting agentom.5. The medical device of claim 4, wherein said wetting agent is selected from the group consisting of heparin coating of polyvinyl alcohol, polyethylene glycol, polypropylene glycol, dextran, agarose, alginate, polyacrylamide, poliglitsidola, poly (vinyl alcohol-co-ethylene), poly (ethylene glycol -co-propylene glycol), poly (vinyl acetate-co-vinyl alcohol), poly (tetrafluoroethylene-co-vinyl alcohol), poly (akriloni
