The invention relates to a compound of Formulae I and/or II: Formula I FormulaII and/or a pharmaceutically-acceptablesalt, hydrate, solvate, tautomer, optical isomer, E-isomer, Z-isomer, orcombination thereof; X is selected from Se, N-OH,NH, NO2, CN, N-CN, N=O, O or S, and the remaining substituents are describedherein; and a composition thereof. The inventionalso relates to a method of administration thereof; and use thereof to treatHIV.