CEE, VICTOR J.,DEAK, HOLLY L.,GEUNS-MEYER, STEPHANIE D.,DU, BINGFAN,HODOUS, BRIAN L.,MARTIN, MATTHEW W.,NGUYEN, HANH NHO,OLIVIERI, PHILIP R.,PANTER, KATHLEEN,ROMERO, KARINA,SCHENKEL, LAURIE,WHITE, RYA
申请号：
ES08742582
公开号：
ES2470341T3
申请日:
2008.04.03
申请国别(地区):
ES
年份:
2014
代理人:
摘要：
Compound of formula I: ** Formula ** or a pharmaceutically acceptable salt thereof, wherein each of A1 is CR2, and A2 is N or CR2； each of A3, A4, A5 and A6, independently, is N or CR3, provided that no more than two of A3, A4, A5 and A6 are N； L1 is -O-, -NR4-, -S-, -C (O) -, -S (O) -, -SO2- or -CR4R4-； L2 is -NR4-； each of A7 and A8, independently, is N； D 'is a 5 or 6-membered carbon atom ring that optionally includes 1-3 heteroatoms selected from O, N and S, and the ring is optionally independently substituted with a number n of R1 substituents； each R1, independently, is halo, C1-10 haloalkyl, C1-10 haloalkoxy, oxo, CN, OH, SH, NO2, NH2, acetyl, C1-10 alkyl, C2-10 alkenyl, C2-10 alkynyl, C3- cycloalkyl 10, C4-10 cycloalkenyl, C1-10 alkylamino, C1-10 dialkylamino, C1-10 alkoxy, C1-10 thioalkoxy, -SR9, -OR9, -NR9R9, -C (O) R9； each R2, independently, is H or halo； each R3, independently, is H, halo, C1-10 haloalkyl, C1-10 haloalkoxy, CN, OH, SH, NO2, NH2, C1-10 alkyl, C2-10 alkenyl, C2-10 alkynyl, C3-10 cycloalkyl, C4-10 cycloalkenyl, C1-10 alkylamino, C1-10 dialkylamino, C1-10 alkoxy, C1-10 thioalkoxy or -C (O) R9； each R4, independently, is H, CN or C1-6 alkyl； R6 is R9； R8 taken together with R7 and the carbon atoms to which they are attached form a ring selected from phenyl, cyclohexyl, thienyl, furyl, pyridyl, pyrimidyl and cyclopentyl, the ring is optionally substituted independently with 1-4 halo substituents, C1 haloalkyl -10, C1-10 haloalkoxy, oxo, CN, OH, SH, NO2, NH2, acetyl, C1-10 alkyl, C2-10 alkenyl, C2-10 alkynyl, C3-10 cycloalkyl, C4-10 cycloalkenyl, C1- alkylamino 10-, C1-10 dialkylamino, C1-10 alkoxy, C1-10 thioalkoxy, SR10, OR10, NR4R10, C (O) R10, COOR10, C (O) NR4R10, NR4C (O) R10, NR4C (O) NR4R10 , NR4 (COOR10), S (O) 2R10, S (O) 2NR4R10, NR4S (O) 2R10, NR4S (O) 2NR4R10 or a fully saturated or partially saturated or partially unsaturated 3-8-membered monocyclic or bicyclic ring system 6-12 members, optionally including said ring system consi
