#$%^&*AU2020200596A120200220.pdf#####Abstract As an antitumor drug which is excellent in terms of antitumor effect and safety and has an excellent therapeutic effect, there is provided an antibody-drug conjugate in which an antitumor compound represented by the following formula is conjugated to an anti-HER2 antibody via a linker having a structure represented by the following formula: -L'-L 2 -LP-NH-(CH 2 )nl-La-(CH 2 )n2C(=O)- wherein the anti-HER2 antibody is connected to the terminal L1, and the antitumor compound is connected to the carbonyl group of the - (CH 2 ) n2 -C (=O) moiety with the nitrogen atom of the amino group at position 1 as the connecting position. [Formula 1] ,NH 2 Me o N F N 0 HO Me
