Bjarnsholt, Thomas,Hoiby, Niels,Jensen, Peter Ostrup,Phipps, Richard,Shanmugham, Meenakshi Sundaram,Gennip, Maria Van,Christensen, Louise Dahl,Jakobsen, Tim Holm,Tanner, David,Larsen, Thomas Ostenfeld
申请号：
AU2016203651
公开号：
AU2016203651B2
申请日:
2016.06.01
申请国别(地区):
AU
年份:
2017
代理人:
摘要：
#$%^&*AU2016203651B220170601.pdf#####Abstract The present invention relates to the compound (E,Z)-ajoene of formula (1) for use in treatment of bacterial infections. Another aspect of the present invention is a composition comprising (E,Z)-ajoene of formula (1) and at least one antibiotic. 5 Yet another aspect of the invention relates to a method for manufacturing (E,Z) ajoene of formula (1) wherein the conformation of the internal -C=C- bond can be either E or Z or a mixture thereof, said method comprising reacting allicin of formula (3) with an acid in the presence of a solvent to provide (E,Z ajoene) of formula (1) as defined above. Yet another aspect of the invention is (E,Z)-ajoene 10 of formula 1 obtainable by the method described above.1/8 0 S Fig. 1
