A filtration medium (14) is sealed within a housing (52, 54). The filtrationmedium (14) is sized and configured to define multiple filtration regions (28,30) within the housing (52, 54), through which independent, though concurrent,blood filtration can occur. Each filtration region (28, 30) is served by itsown inlet path, which conveys blood into the filtration region (28, 30). Thefiltration medium (14) in each region (28, 30) passes the blood to remove atleast one undesired component, such as leukocytes. After filtration, themultiple regions (28, 30) convey the blood into a single, centrally locatedmanifold (36). A single outlet (18) communicates with the manifold (36).