THE GOVERNMENT OF THE UNITED STATES OF AMERICA; REPRESENTED BY THE SECRETARY; DEPARTMENT OF HEALTH AND HUMAN SERVICES
发明人:
DUDLEY, MARK E.,ROSENBERG, STEVEN A.,WUNDERLICH, JOHN R.
申请号：
CA2497552
公开号：
CA2497552C
申请日:
2003.09.05
申请国别(地区):
CA
年份:
2014
代理人:
摘要：
A method of promoting the regression of a cancer in a mammal comprising: (i)administering to the mammal nonmyeloablative lymphodepleting chemotherapy, and(ii) subsequently administering: (a) autologous T-cells, which have beenpreviously isolated, selected for highly avid recognition of an antigen of thecancer, the regression of which is to be promoted, and rapidly expanded invitro only once, and, either concomitantly with the autologous T-cells orsubsequently to the autologous T-cells, by the same route or a differentroute, a T-cell growth factor that promotes the growth and activation of theautologous T-cells, or (b) autologous T-cells, which have been previouslyisolated, selected for highly avid recognition of an antigen of the cancer,the regression of which is to be promoted, modified to express a T-cell growthfactor that promotes the growth and activation of the autologous T-cells, andrapidly expanded in vitro only once, whereupon the regression of the cancer inthe mammal is promoted.
