Method for operating a CNC machine (1) for machining a dental workpiece (2), wherein - when the CNC machine (1) is operated in a machining mode (BM) - the dental workpiece clamped in a clamping device (3) 2) by a processing device (4) of the CNC machine (1) is processed, wherein - when the CNC machine (1) is operated in a calibration (KM) - based on a test specimen (5) at least one calibration parameter (K) CNC machine (1) checked and at least one correction value (Q) is set, wherein the CNC machine (1) in the processing mode (BM) in dependence of the at least one correction value (Q) is operated.