Short-acting Factor VII peptides are disclosed. A shortened half-life is desirable for treatment of acute bleeding and similar disorders. Modification of the sialylation and/or glycosylation of Factor VII and variants thereof produced peptides useful in treating conditions of acute bleeding.本發明揭示短-作用因子VII多肽。對於治療急性出血以及類似病症來說,半衰期縮短是所欲的。因子VII及其變異體的唾液酸化及/或醣化修飾產生可用於治療急性出血病況的肽。