PURPOSE: A flavonoid compound derived from Vitex rotundifolia is provided to reduce Bcl-2 expression in cancer cells and to induce cancer cell apoptosis. CONSTITUTION: A pharmaceutical composition for preventing and treating cancer contains Vitex rotundifolia extract as an active ingredient. The extract is isolated using methylene chloride or methanol. The extract is also H_2O, n-BuOH, 85% aq. MeOH, or n-hexane fraction. A pharmaceutical composition for preventing or treating cancer contains flavonoid compounds of chemical formula 1 derived from Vitex rotundifolia or pharmaceutically acceptable salt thereof as an active ingredient. The cancer is gastric cancer, fibrosarcoma, or breast cancer. A health food composition for preventing or treating cancer contains Vitex rotundifolia extract as an active ingredient.본 발명은 순비기나무 추출물 또는 그로부터 유래한 하기 화학식 I의 플라보노이드계 화합물 또는 이의 약제학적으로 허용가능한 염, 및 이를 유효성분으로 함유하는 암의 예방, 치료 또는 억제용 약학 조성물을 제공한다.<；화학식 I>；상기 식에서,R1, R4 및 R5는 각각 OH 또는 OMe이며,R2 및 R3는 각각 H 또는 OMe이다.
