INTERFERON &alpha；2B VARIANTS

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专利权人:

TEVA PHARMACEUTICALS AUSTRALIA PTY LTD

发明人:

BEHRENS, COLLETTE,DOYLE, ANTHONY,CLARKE, ADAM,POLLARD, MATTHEW,DOMAGALA, TERESA

申请号：

SG11201703251T

公开号：

SG11201703251TA

申请日:

2015.10.23

申请国别(地区):

SG

年份:

2017

代理人:

摘要：

The present invention provides a fusion polypeptide comprising a first domain and a second domain, wherein the first domain comprises a polypeptide ligand which binds to a cell surface-associated antigen and the second domain comprises aglycosylated interferon &alpha； 2b (IFN&alpha；2b) having a sequence of SEQ ID NO: 1 or SEQ ID NO: 2. The aglycosylated IFN&alpha；2b further comprises one or more amino acid substitutions or deletions which attenuate the activity of the aglycosylated IFN&alpha；2b.

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