ANTICORPS BISPECIFIQUES ANTI-MUC16-CD3 ET CONJUGUES MEDICAMENT ANTI-MUC16

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专利权人:

INC.;REGENERON PHARMACEUTICALS

发明人:

HABER, LAURIC,SMITH, ERIC,KELLY, MARCUS,KIRSHNER, JESSICA R.,COETZEE, SANDRA,CRAWFORD, ALISON,NITTOLI, THOMAS,LIU, YASHU

申请号：

CA3037738

公开号：

CA3037738A1

申请日:

2017.09.22

申请国别(地区):

CA

年份:

2018

代理人:

摘要：

The present disclosure provides anti mucin 16 antibodies : bispecific antibodies (bsAbs) that bind to both MUC16 and CD3 and activate T cells via the CD3 complex in the presence of MUC16-expressing tumors. human IgG antibodies that bind to human andMUC16 (monospecific antibodies).anti-MUC16 antibody drug conjugates which inhibit tumor growth in vivo The antibodies are useful for the treatment of various cancers, including ovarian cancer.

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