The Brigham And Womens Hospital Inc.;The Brigham And Women's Hospital Inc.
发明人:
SERHAN, Charles,YANG, Rong
申请号：
ES09815065
公开号：
ES2569371T3
申请日:
2009.09.15
申请国别(地区):
ES
年份:
2016
代理人:
摘要：
A compound comprising formula (I): ** Formula ** where each of P1 and P2 is individually a protective group or a hydrogen atom； where is a double bond； where the double bonds in positions 4, 16 and 19 are each of configuration Z and the double link in position 10 is of configuration E； where Z is -C (O) ORd, -C (O) NRcRc, -C (O) H, -C (NH) NRcRc, -C (S) H, -C (S) ORd, -C (S) NRcRc or -CN； each Ra is independently selected hydrogen, (C1-C6) alkyl, cycloalkyl (C3-C8), cyclohexyl, cycloalkylalkyl (C4-C11), aryl (C5-C10), phenyl, arylalkyl (C6-C16), benzyl, heteroalkyl of 2-6 members, 3-8 membered cycloheteroalkyl, morpholinyl, piperazinyl, homopiperazinyl, piperidinyl, 4-11 membered cycloheteroalkylalkyl, 5-10 membered heteroaryl or 6-16 membered heteroarylalkyl； each Rc is independently a protective group or Ra or, alternatively, each Rc is taken together with the nitrogen atom to which it is attached forming a 5- to 8-membered cycloheteroalkyl or heteroaryl which may optionally include one or more of the same or different additional heteroatoms, and which may be optionally substituted with one or more of the same or different suitable Ra or Rb groups； each Rb is independently selected from>； = O, -ORd, halogenoalkyloxy (C1-C3), -OCF3,>； = S, -SRd,>； = NRd,>； = NORd, -NRcRc, halogen, -CF3, -CN, - NC, -OCN, -SCN, -NO, -NO2,>； = N2, -N3, -S (O) Rd, S (O) 2Rd, -S (O) 2ORd, -S (O) NRcRc, - S (O) 2NRcRc, -OS (O) Rd, -OS (O) 2Rd, -OS (O) 2ORd, -OS () 2NRcRc, -C (O) Rd, -C (O) ORd, -C (O ) NRcRc, -C (NH) NRcRc, - C (NRa) NRcRc, -C (NOH) Ra, -C (NOH) NRcRc, -OC (O) Rd, -OC (O) ORd, -OC (O) NRcRc, -OC (NH) NRcRc, -OC (NRa) NRcRc, - [NHC (O)] nRd, - [NRaC (O)] nRd, -LNHC (O)] nORd, -LNRaC (O)] nORd - [NHC (O)] nNRcRc, - [NRaC (O)] nNRcRc, - [NHC (NH)] nNRcRc or - [NRaC (NRa)] nNRcRc； each n is, independently, an integer from 0 to 3； and each Rd is, independently, a protective group or Ra； where "alkyl" by itself or as part of another substituent refers to a branched,
