An applicator device includes a formulation assembly with a dispenser portion and one or more formulation reservoirs, the formulation assembly being operable to dispense a formulation from the one or more formulation reservoirs onto one or more regions of a biological surface. The applicator device also includes a photo-dose assembly operably coupled to the formulation assembly, the photo-dose assembly having at least one illuminator oriented to focus electromagnetic energy onto one or more focal regions of a biological surface.