Methods and apparatus to determine efficiencies of media delivery across platforms are disclosed. An example method includes measuring, with a sensor, first neuro-response data from a person when exposed to media output via a first media delivery platform type. Measuring second neuro-response data from the person when exposed to media output via a second media delivery platform type, different than the first media delivery platform type. Accessing a first and second performance metric for the respective media delivery platform type, the performance metrics based on a first and second reach of the respective media delivery platform types with respect to a target group of audience members. Accessing a first and second effectiveness metric for the respective media delivery platform types, the effectiveness metric based on the respective neuro-response data. Rating at least one of the first or second media delivery platform types based on the first and the second platform metrics.