Abstract: The present invention relates to a topical pharmaceutical composition comprising a combination of two or more orally or systemically administered active ingredients e.g. methotrexate, acitretin and cyclosporine a process for producing the same and the use of the composition in the treatment of psoriasis, atopic dermatitis and chronic eczema. The composition of this invention can be used alone or in combination with other topical or systemic therapies.
