Paul T. Spellman,Joe W. Gray,Anguraj Sadanandam,Laura M. Heiser,William J. Gibb,Wen-lin Kuo,Nicholas J. Wang
申请号：
US13401780
公开号：
US09506926B2
申请日:
2012.02.21
申请国别(地区):
US
年份:
2016
代理人:
摘要：
Herein is described the use of a collection of 50 breast cancer cell lines to match responses to 77 conventional and experimental therapeutic agents with transcriptional, proteomic and genomic subtypes found in primary tumors. Almost all compounds produced strong differential responses across the cell lines produced responses that were associated with transcriptional and proteomic subtypes and produced responses that were associated with recurrent genome copy number abnormalities. These associations can now be incorporated into clinical trials that test subtype markers and clinical responses simultaneously.
