PROBLEM TO BE SOLVED: To provide an easily takable novel cAMP phosphodiesterase inhibitor made of easily available raw materials.SOLUTION: A cyclic AMP phosphodiesterase inhibitor includes an extract from Ilex paraguariensis belonging to Aquifoliaceae Ilex known as a raw material of mate. Beverages or foods for promoting fat combustion including an extract from Ilex paraguariensis are also provided.【課題】原料の入手が容易で、服用しやすい新規のｃＡＭＰホスホジエステラーゼ阻害剤の提供。【解決手段】マテ茶の原料として知られるモチノキ科モチノキ属のイェルバ・マテ（Ilex paraguariensis）からの抽出物を含有する、サイクリックＡＭＰホスホジエステラーゼ阻害剤。さらに、イェルバ・マテ（Ilex paraguariensis）からの抽出物を含有する脂肪燃焼促進用飲料、または脂肪燃焼促進用食品。【選択図】なし
