CARLOS GARCIA-ECHEVERRIA,CHRISTINE FRITSCH,DARRIN STUART,SAUVEUR-MICHEL MAIRA,SUSAN WEE,TOBI NAGEL
申请号：
BRPI0915901
公开号：
BRPI0915901A2
申请日:
2009.07.10
申请国别(地区):
BR
年份:
2015
代理人:
摘要：
The invention relates to a pharmaceutical combination which comprises (a) a phosphoinositide 3-kinase inhibitor compound and (b) a compound which modulates the Ras/Raf/Mek pathway for the treatment of a proliferative disease, especially a solid tumor disease； a pharmaceutical composition comprising such a combination； the use of such a combination for the preparation of a medicament for the treatment of a proliferative disease； a commercial package or product comprising such a combination as a combined preparation for simultaneous, separate or sequential use； and to a method of treatment of a warm-blooded animal, especially a human.
