檢測磷酸化α-突觸核蛋白的方法

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专利权人:

Prothena Biosciences Limited

发明人:

BARBOUR, Robin,ZIESKE, Lynn R.,HAMREN, Sarah

申请号：

HK18116355

公开号：

HK1257103A1

申请日:

2018.12.20

申请国别(地区):

HK

年份:

2019

代理人:

摘要：

The invention provides methods of detecting alpha-synuclein using a capture antibody and a reporter antibody. The capture antibody binds preferentially to full-length alpha-synuclein phosphorylated at residue 129 (PS129 alpha-synuclein) over unphosphorylated full-length alpha-synuclein. The 11A5 antibody is an example of a suitable capture antibody. The reporter antibody binds to an epitope within residues 40-55 of alpha-synuclein. The 23E8 antibody is an example of such an antibody. Because only a small proportion of alpha-synuclein is phosphorylated high sensitivity of detection below picomolar is advantageous.

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