594344 Disclosed is the use of a combination comprising (a) at least one ion selected from the group of the hypothiocyanites and/or hypohalites and (b) lactoferrin for preparing a pharmaceutical composition suitable for local administration to the pulmonary epithelium in the longterm treatment of cystic fibrosis and associated pulmonary infections, wherein the pharmaceutical composition comprises at least 1 mg of lactoferrin for every 25?M of ion (a), and wherein the composition comprises less than 1 ppm of each of glucose oxidase, lactoperoxidase, and hydrogen peroxide. Further disclosed is a pharmaceutical composition for daily local administration to the pulmonary epithelium in the treatment of cystic fibrosis and associated pulmonary infections comprising about 250 ?M of OSCN- ion, up to 2.4 mM of SCN- ion and up to 2.6 mM of lactoferrin, wherein the composition comprises less than 1 ppm of each of glucose oxidase, lactoperoxidase, and hydrogen peroxide； and wherein the composition is suitable for administration via inhalation from a sprayer, nebulizer or aerosolizer at a rate of 1 ml to 5 ml of solution per inhalation so as reach target sites within the lungs.
