An implantable vital sign sensor including a housing including a first portion the first portion defining a first open end a second open end opposite the first end and a lumen there through the first portion being sized to be implanted substantially entirely within the blood vessel wall of the patient. A sensor module configured to measure a blood vessel blood pressure waveform is included the sensor module having a proximal portion and a distal portion the distal portion being insertable within the lumen and the proximal portion extending outward from the first open end.
