This method, which screens drugs that activate the skin, is characterized by causing candidate drugs to act on vascular endothelial cells, and selecting drugs that enhance the expression of PDGF-BB by the cells as a skin activation agent.本發明係一種方法,其特徵在於:其係篩選使皮膚活化之藥劑之方法,且選擇使候補藥劑作用於血管內皮細胞,從而促進上述細胞之PDGF-BB之表現之藥劑作為皮膚活化劑。