The present invention provides a novel complex comprising a) a cell penetrating peptide b) at least one antigen or antigenic epitope and c) at least one TLR peptide agonist wherein the components a) c) are covalently linked. Moreover the present invention also provides a nucleic acid encoding such a complex wherein the complex is a peptide or a protein. Such a nucleic acid may be comprised by a vector and such a vector may be comprised by a host cell. In particular compositions such as a pharmaceutical compositions and vaccines are provided which may be useful for example in the prevention and/or treatment of a diseases and/or a disorder including cancer hematological disorders infectious diseases autoimmunity disorders and transplant rejections.
