The invention relates to the preparation of placental growth factor (PLGF)-comprising therapeutic and cosmetic compositions capable of increasingangiogenesis of the cutaneous, subcutaneous and internal organ connectivetissue. Such compositions are suitable for the treatment of pathological ornatural states benefiting from the formation or regeneration of new vessels ofthe cutaneous compartment, such as scleroderma , its various manifestations,skin ageing or loss of hair.