An ambulatory assist device provides mobility assistance for an ambulatory transition between seated and standing positions. A mobile frame defines a structure similar to a walker device. The mobile frame includes a plurality of wheels for rolling communication with a ground surface. Lift arms, driven by an actuator, pivot around an axis of a cross member attached to the frame. The lift arm is configured for actuated pivotal movement for an ambulatory transition between seated and standing positions by a harness engaging the patient. The pivot is based on an arc of patient movement between the sitting and standing positions, such that the arc emulates natural movements of a human skeletal frame during an ambulatory transition. The patient experiences forces along the same path that an unassisted transition would encounter. Once in an ambulatory position, the device allows ambulatory movement in a manner similar to a walking assist (walker) device.