Archana Swami,Pamela Basto,Jeffrey Karp,Omid C. Farokhzad
申请号：
US14531466
公开号：
US20150125391A1
申请日:
2014.11.03
申请国别(地区):
US
年份:
2015
代理人:
摘要：
Bone- and metal-targeted polymeric nanoparticles are provided. Exemplary nanoparticles have three main components: 1) a targeting element that can selectively bind to bone, minerals, or metal ions 2) a layer of stealth to allow the polymer to evade immune response and 3) a biodegradable polymeric material, forming an inner core which can carry therapeutics or other diagnostics. Preferred nanoparticles contain a blend of target-element polymer conjugate and polymer that optimizes the ligand density on the surface of the nanoparticle to provide improved targeting of the nanoparticle. The ratio of target-element polymer conjugate to polymer can also be optimized to improve the half-life of the nanoparticles in the blood of the subject. The nanoparticles also exhibit prolonged, sustained release of therapeutic agents loaded into the particles.
