The present invention is directed to chitosan-derivative compounds andstructures,methods of making chitosan-derivative compounds and methods for controlling,inhibiting andenhancing microbial populations in a variety of environments. The presentinvention is alsodirected to the control, inhibition and enhancement of microbial populationsin animals,particularly humans. The microbial populations include bacteria, viruses andother pathogenswhere control of microbial populations are a necessity. The chitosan-derivative compounds ofthe present invention include chitosan-arginine compounds, related chitosan-L/D unnaturalamino acid compounds, chitosan-acid amine compounds, chitosan-L/D naturalamino acidderivative compounds, co-derivatives of the chitosan-derivative compounds,salts of the chitosanderivative compounds, and chitosan-guanidine compounds.