Methods and devices for locking and tagging a medical tube are disclosed. The locking device connects to a medical tube and restricts full manipulation of the medical tube. The locking and tagging devices can communicate instructions or notices relevant to the medical tube, including its placement, purpose, function, operation, care, maintenance, removal, replacement, indication of manipulation or tampering, as well as the patient's healthcare information and health care provider information. In some configurations, the tagging device may be configured to communicate instructions and notices as a primary function, with or without a locking function.
