Andrew Geall;Luis Brito;Manmohan Singh;Derek O'Hagan
发明人:
Luis Brito,Andrew Geall,Derek O'Hagan,Manmohan Singh,Derek OHagan
申请号：
US13235454
公开号：
US09295646B2
申请日:
2011.09.18
申请国别(地区):
US
年份:
2016
代理人:
摘要：
This invention generally relates to cationic oil-in-water emulsions that can be used to deliver negatively charged molecules, such as an RNA molecule. The emulsion particles comprise an oil core and a cationic lipid. The cationic lipid can interact with the negatively charged molecule thereby anchoring the molecule to the emulsion particles. The cationic emulsions described herein are particularly suitable for delivering nucleic acid molecules (such as an RNA molecule encoding an antigen) to cells and formulating nucleic acid-based vaccines.
