This application involves treat and prevent neural skin barrier, the neural skin barrier such as mediated by Tuberous Sclerosis Complex (TSC), such as the method for tuberous sclerosis and the tuberous sclerosis such as mediated by 1 type neurofibromatosis. Nerve skin barrier used herein includes the obstacle mediated by Tuberous Sclerosis Complex (TSC), such as tuberous sclerosis and associated disorders and 1 type neurofibromatosis and associated disorders. Present invention also provides the rapamycin derivatives that neural skin barrier is treated with what.本申請涉及治療和預防神經皮膚障礙，諸如通過複合性結節性硬化病(TSC)介導的神經皮膚障礙，例如結節性硬化症和諸如通過1型神經纖維瘤病介導的結節性硬化症的方法。本文所用的神經皮膚障礙包括通過複合性結節性硬化病(TSC)介導的障礙，例如結節性硬化症和相關障礙和1型神經纖維瘤病和相關障礙。本申請還提供了用於治療神經皮膚障礙的雷帕霉素衍生物。
