A drug delivery balloon apparatus and methods for use, where the drug delivery balloon apparatus comprises: (a) at least two lumens, comprising a first lumen and a second lumen, (b) a balloon inflation port in communication with the first lumen, (c) a drug delivery port in communication with the second lumen, (d) a guidewire port in communication with either the second lumen or a third lumen, (e) an occlusion balloon, (f) a drug delivery balloon having an outer surface with a plurality of grooves, where the occlusion balloon is disposed between the drug delivery balloon and the balloon inflation port, and the occlusion and drug delivery balloons are in communication with the first lumen, (g) one or more drug delivery channels extending the length of the second lumen, and (h) one or more drug delivery ducts extending from the one or more drug delivery channels to an exterior surface of the second lumen.
