An electrophysiology data acquisition system that receives physiological signals from at least one catheter includes an amplifier and at least one noise reduction circuit operatively connected to the amplifier and configured to cancel interference in the physiological signals from the catheter. A drive selection circuit is controllable to connect any one of two or more available electrodes to the noise reduction circuit such that the connected electrode becomes an equalization drive electrode for the catheter. An equalization control module is executable on a processor and configured to select the equalization drive electrode from the two or more available electrodes and to control the drive selection circuit to connect the selected equalization drive electrode to the noise reduction circuit.
