The object is to discover a pharmaceutical composition having an excellent anti-tumoreffect and a therapeutic method for cancer. 4-(3-Chloro-4-(cyclopropylaminocarbonyl)aminophenoxy)-7-methoxy-6-quinolinecarboxamide, an analogous compound or pharmacologicallyacceptable salt thereof, or a solvate of the compound or the analogous compoundor pharmacologically acceptable salt can exhibit an excellent anti-tumor effectwhen used in combination with a taxane.