Denise Demarals,Hanson Gifford, III,Mark Deem,Howard R. Levin,Mark Gelfand,Nicolas Zadno
申请号：
US11403329
公开号：
US08131371B2
申请日:
2006.04.13
申请国别(地区):
US
年份:
2012
代理人:
摘要：
Methods and apparatus are provided for monopolar neuromodulation, e.g., via a pulsed electric field. Such monopolar neuromodulation may effectuate irreversible electroporation or electrofusion, necrosis and/or inducement of apoptosis, alteration of gene expression, action potential attenuation or blockade, changes in cytokine up-regulation and other conditions in target neural fibers. In some embodiments, monopolar neuromodulation is applied to neural fibers that contribute to renal function. In some embodiments, such monopolar neuromodulation is performed bilaterally.
