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N,N′-hydrazino-bis-isatin derivatives with selective activity against multidrug-resistant cancer cells
专利权人:
Tarek Aboul-Fadl Mohamed Hassan
发明人:
Tarek Aboul-Fadl Mohamed Hassan,Adnan Ahmed Kadi,Hatem Abdel-Khader Abdel-Aziz
申请号:
US13423040
公开号:
US08497296B2
申请日:
2012.03.16
申请国别(地区):
US
年份:
2013
代理人:
摘要:
The invention is directed to a compound of Formula (I),wherein R is selected from the group consisting of hydrogen atom and unsubstituted or substituted phenyl group R1 is selected from the group consisting of hydrogen atom and unsubstituted or substituted phenyl group X is selected from the group consisting of hydrogen atom or halogen atom and Y is selected from the group consisting of hydrogen atom, halogen atom, C1-C4 alkyl group, nitro group, and —OCF3 group, as well as for its use in therapy, preferably for the treatment of cancer, and to a related pharmaceutical composition, the use of the compound for the manufacture of a medicament for the respective medical indication, and a method of synthesis of the compounds of the invention.
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