1. An immunogenic composition comprising: (i) a conjugated pneumococcal capsular saccharide； and (ii) two different polypeptides of the factor H-binding protein (fHBP), but not containing mesococcus outer membrane vesicles, where two different fHBP polypeptides are either (a) a first polypeptide comprising an amino acid sequence having at least 85% sequence identity with SEQ ID NO: 1, and / or comprising an amino acid sequence consisting of a fragment of at least 7 consecutive amino acids from SEQ ID NO: 1； and a second polypeptide comprising an amino acid sequence having at least 85% sequence identity with SEQ ID NO: 3, and / or comprising an amino acid sequence consisting of a fragment of at least 7 consecutive amino acids from SEQ ID NO: 3, or (b ) a first polypeptide comprising an amino acid sequence having at least 85% sequence identity with SEQ ID NO: 1, and / or comprising an amino acid sequence consisting of a fragment of at least 7 consecutive amino acids from SEQ ID NO: 1； and a second polypeptide comprising an amino acid sequence having at least 85% sequence identity with SEQ ID NO: 2, and / or comprising an amino acid sequence consisting of a fragment of at least 7 consecutive amino acids from SEQ ID NO: 2.2. An immunogenic composition comprising: (i) a conjugated pneumococcal capsular saccharide； and (ii) meningococcal factor H-binding protein antigen (fHBP), which is lipidated at the N-terminal cysteine residue, but not containing meningococcal outer membrane vesicles1. Иммуногенная композиция, содержащая:(i) конъюгированный пневмококковый капсульный сахарид； и(ii) два различных полипептида фактор H-связывающего белка (fHBP), но не содержащая везикулы внешней мембраны менингококка, где два различных полипептида fHBP представляют собой либо(a) первый полипептид, включающий аминокислотную последовательность, имеющую по меньшей мере 85% идентичности последовательности с SEQ ID NO:1, и/или включающий аминокислотную последовательность, состоящую из фрагмент
