EUROPEAN EGYPTIAN PHARMACEUTICAL INDUSTRIES (EEPI);MONA BAKR MOHAMED MAHMOUD;NANOTECH FOR PHOTOELECTRONICS RESEARCH;SHERINE HASSAN ABBAS HELMY
发明人:
MONA BAKR MOHAMED MAHMOUD,SHERINE HASSAN ABBAS HELMY
申请号：
BR112015021212
公开号：
BR112015021212A2
申请日:
2013.10.29
申请国别(地区):
BR
年份:
2017
代理人:
摘要：
Abstract “Iron based nanocomposite formula for fast and efficient treatment of iron deficiency anemia”. These are iron oxide nanoparticle formulas coated with a mixture of multivitamins such as folic acid, nicotinic acid (vitamin b9) and ascorbic acid (vitamin c) were developed for the rapid and efficient treatment of fatal iron deficiency anemia. a single small dose of multivitamin iron oxide nanocomposite from 25 mg elemental iron per dose is sufficient to increase hemoglobin level from 4.4 g / dl to up to 14.6 g / dl in just four days after the administration. The multivitamin that is used in this nanocomposite significantly improves iron absorption and elevates hemoglobin concentration. Two iron nanocomposite dosage forms were developed, gel capsules and aqueous solution for oral administration. Animal studies show that introducing a single dose of iron oxide vitamin nanocomposites containing 2.57 mg elemental iron per kg rat body weight (equal to 25 mg in humans) is sufficient to correct hemoglobin level and cure anemia. by oral administration. The toxicity study reveals that the ld50 of our new iron nanocomposite is 1425.3 mg / kg rat body weight, which means that the ld50 of nanoscale iron nanocomposites in humans (weight 60 kg) is of 13,854 mg. thus, the single dose required for rapid treatment of iron deficiency anemia is 554 times lower than ld50 in humans. no sign of any toxicity in haematological, biochemical or histopathological studies. In addition, bone marrow histopathology study suggests that iron oxide vitamin nanocomposites increase the number of rcb precursors that stimulate bone marrow to produce more red blood cells.resumo “fórmula de nanocompósitos com base de ferro para tratamento rápido e eficiente de anemia ferropriva”. trata-se de fórmulas de nanopartículas de óxidos de ferro cobertas com uma mistura de multivitaminas tais como ácido fólico, ácido nicotínico (vitamina b9) e ácido ascórbico (vitamina c) foram desenvolvidas para o tratamento
