THE SUBJECT INVENTION PROVIDES A DRUG DELIVERY SYSTEM COMPRISING AT LEAST ONE COMPARTMENT COMPRISING (i) A DRUG-LOADED THERMOPLASTIC POLYMER CORE LAYER. (ii) A DRUG-LOADED THERMOPLASTIC POLYMER INTERMEDIATE LAYER AND (iii) A NON-MEDICATED THERMOPLASTIC POLYMER SKIN COVERING THE INTERMEDIATE LAYER, WHEREIN SAID CORE LAYER IS LOADED WITH CRYSTALS OF A FIRST (PHARMACEUTICALLY) ACTIVE COMPOUND AND SAID INTERMEDIATE LAYER IS LOADED WITH CRYSTALS OF THE SECOND (PHARMACEUTICALLY) ACTIVE COMPOUND. FIGURE IC