#$%^&*AU2020203914A120200702.pdf#####75 ABSTRACT The present disclosure describes a closed-loop fluid resuscitation and/or cardiovascular drug administration system that uses continuous measurements and adaptive control architecture. The adaptive control architecture uses a function approximator to identify unknown dynamics and physiological parameters of a patient to compute appropriate infusion rates and to regulate the endpoint of resuscitation.1/36 Resuscitation Fluid (Crystalloid/Colloid) Fluid E xchange Circulation lw Interstitial (Blood) Tissue Urine Blood Evaporation FIG.1A
