The present invention provides a compound excellent in suppression of autotoxin and the likes, and useful as a prophylactic or therapeutic medication for ATX joint diseases. The present invention is relates to a compound represented by the following general formula (1): [In the formula, each symbol is the same as recited in the specification], these compounds are excellent in suppression of autotoxin and the likes, and useful as a prophylactic or therapeutic medication for ATX joint diseases.本發明係提供一種自家趨化素(autotaxin)抑制作用等優越，作為ATX參予疾病之預防或治療藥有效之化合物。本發明係有關下述通式(1)表示之化合物：[式中之各符號如說明書中記載]，該等具有優越之自家趨化素抑制作用，可使用作為ATX參予之疾病之預防或治療藥。
