VEGF-binding molecules, preferably VEGF-binding immunoglobulin single variable domains like VHHs and domain antibodies, pharmaceutical compositions containing same and their use in the treatment of diseases that are associated with VEGF-mediated effects on angiogenesis. Nucleic acids encoding VEGF-binding molecules, host cells and methods for preparing same.本發明揭示VEGF-結合分子,較佳為VEGF-結合性免疫球蛋白單一可變結構域(如VHH及結構域抗體)抗體,含有其之醫藥組合物及其在治療與VEGF所調介血管發生之效應相關的疾病中的用途。本發明揭示編碼VEGF-結合分子之核酸、宿主細胞及其製備方法。(無元件符號說明)