Process for synthesis of a diarylpyrimidine non-nucleoside reverse transcriptase inhibitor

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专利权人:

EMCURE PHARMACEUTICALS LIMITED

发明人:

GURJAR MUKUND KESHAV,MAIKAP GOLAKCHANDRA SUDARSHAN,JOSHI SHASHIKANT GANGARAM

申请号：

AP2011005715

公开号：

AP2858A

申请日:

2010.06.18

申请国别(地区):

AP

年份:

2014

代理人:

摘要：

A method for synthesis of diarylpyrimidine non-nucleoside reverse transcriptase inhibitor such as etravirine is provided Typically, etravirine is synthesized by the steps of a Condensing 2,4,6-trichlorpyrimidine with 3,5-dimethyl-4-hydroxybenzonitrile to obtain compound (V), b Condensing compound (V) with 4-aminobenzonitrile to obtain compound (VI), c Ammonolysis of compound (VI) to get compound (IV), d Halogenation of compound (IV) to get etravirine.

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