An adhesive single chamber deep vein thrombosis prevention garment includes a body having a central panel, a left side panel, and a right side panel formed with attachment straps having hook and loop integral fasteners. The central panel is formed to have a single air chamber which receives air from a pump through a flexible air supply tube. The inside of the single air chamber is coated with a tacky adhesive layer providing distal-to-proximal sequential inflation as air is progressively introduced into the chamber, thereby creating a distal-to-proximal pressure gradient on a patients limb. The central, left side and right side panels are formed from a single material which does not require a skin-safe liner or other combination of materials. A cover panel attached to the central panel to cover the single-chamber bladder and the body is made from the same material which can be placed against a patients skin.